The human side of research medicine is the focus of this account of three patients participating in clinical trials of new drugs for the treatment of AIDS and cancer. In 1995 and 1996 science writer Kelly (co-author with Thomas Verny of The Secret Life of the Unborn Child, not reviewed) spent some 200 hours with Edward Sandisfield, Romy Hochman, and Julie Conte as they faced life-threatening diseases. Sandisfield, a middle-age gay man knowledgeable about AIDS and its treatment, was so desperate to win a place in the clinical trial at Bellevue of a new protease inhibitor, indivir, in combination with AZT and 3TC, that he was prepared to lie his way into the program if necessary. The Hochmans put their 14-year-old daughter with osteosarcoma (a form of bone cancer that frequently metastasizes to the lungs) into a clinical trial at NYU Medical Center to boost her chances of survival; however, Romy was randomized into the control group, receiving only standard treatment. Conte, a 34-year-old woman with breast cancer, was leery of joining a clinical trial testing a high-dose combination-drug therapy, but having already lost her mother and one sister to the disease, she entered the program at Fox Chase Cancer Center in Pennsylvania. Kelly stayed with his three subjects during exams, interviews, and treatment, observing them and talking to them about their experiences, their hopes, and their fears, and interviewing their families, friends, and doctors. Some conversations seem to be reported verbatim, at times giving the stories an up-close and personal feel. In each, Kelly inserts an essay on the disease and the treatment being tested. While the stories end with all three patients alive, an afterword reveals that by 1997 one had succumbed. Kelly’s discussion of the medicine is thorough, but the portraits of his subjects are uneven. Sandisfield’s story is the most complete and his character and his world the best delineated; by comparison, Conte’s story seems sketchy, and the teenager Hochman remains opaque.
Pub Date: Jan. 12, 1999
ISBN: 0-553-10113-7
Page Count: 352
Publisher: Bantam
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Nov. 15, 1998
An enjoyable slice of 20th-century music journalism almost certain to provide something for most readers, no matter one’s...
Music journalist and musician Wald (Talking 'Bout Your Mama: The Dozens, Snaps, and the Deep Roots of Rap, 2014, etc.) focuses on one evening in music history to explain the evolution of contemporary music, especially folk, blues, and rock.
The date of that evening is July 25, 1965, at the Newport Folk Festival, where there was an unbelievably unexpected occurrence: singer/songwriter Bob Dylan, already a living legend in his early 20s, overriding the acoustic music that made him famous in favor of electronically based music, causing reactions ranging from adoration to intense resentment among other musicians, DJs, and record buyers. Dylan has told his own stories (those stories vary because that’s Dylan’s character), and plenty of other music journalists have explored the Dylan phenomenon. What sets Wald's book apart is his laser focus on that one date. The detailed recounting of what did and did not occur on stage and in the audience that night contains contradictory evidence sorted skillfully by the author. He offers a wealth of context; in fact, his account of Dylan's stage appearance does not arrive until 250 pages in. The author cites dozens of sources, well-known and otherwise, but the key storylines, other than Dylan, involve acoustic folk music guru Pete Seeger and the rich history of the Newport festival, a history that had created expectations smashed by Dylan. Furthermore, the appearances on the pages by other musicians—e.g., Joan Baez, the Weaver, Peter, Paul, and Mary, Dave Van Ronk, and Gordon Lightfoot—give the book enough of an expansive feel. Wald's personal knowledge seems encyclopedic, and his endnotes show how he ranged far beyond personal knowledge to produce the book.
An enjoyable slice of 20th-century music journalism almost certain to provide something for most readers, no matter one’s personal feelings about Dylan's music or persona.Pub Date: July 25, 2015
ISBN: 978-0-06-236668-9
Page Count: 368
Publisher: Dey Street/HarperCollins
Review Posted Online: May 15, 2015
Kirkus Reviews Issue: June 1, 2015
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
BOOK TO SCREEN
BOOK TO SCREEN
BOOK TO SCREEN
This is not the Nutcracker sweet, as passed on by Tchaikovsky and Marius Petipa. No, this is the original Hoffmann tale of 1816, in which the froth of Christmas revelry occasionally parts to let the dark underside of childhood fantasies and fears peek through. The boundaries between dream and reality fade, just as Godfather Drosselmeier, the Nutcracker's creator, is seen as alternately sinister and jolly. And Italian artist Roberto Innocenti gives an errily realistic air to Marie's dreams, in richly detailed illustrations touched by a mysterious light. A beautiful version of this classic tale, which will captivate adults and children alike. (Nutcracker; $35.00; Oct. 28, 1996; 136 pp.; 0-15-100227-4)
Pub Date: Oct. 28, 1996
ISBN: 0-15-100227-4
Page Count: 136
Publisher: Harcourt
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Aug. 15, 1996
BOOK REVIEW
BOOK REVIEW
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