No other bestselling author crunches the language quite like Cook, but he does know how to make his pages fly—which is what made last year's dull Blindsight so unforgivable. Not so this newest, which finds Cook back on track—like a runaway locomotive- -with a manically entertaining thriller. Sean Murphy is a brash son of Boston's Irish ghetto, a reformed thief whose brains have gotten him into Harvard Med. Now Sean's heading for Miami's Forbes Cancer Center, which has a mysterious 100% success rate treating medulloblastoma, a type of brain cancer. Once south, though, Sean finds that the Center's head, Randolph Mason, wants him to work not on the ``medulloblastoma protocol'' but on crystallizing ``murine monoclonal antibodies'' (Cook pours on the medical know-how here). Moreover, Janet Reardon, the nurse/lover Sean dumped in Boston, has followed Sean to Forbes. But never mind: Sean decides to steal Forbes's research and give it to the world, and to enlist Janet's help. When Forbes's Japanese backers learn of Sean's aim, though, they send an assassin after him; but the killer has to get in line behind the p.i. that Mason has hired to look into Sean, and the Nazi-like head of Forbes security—not to mention Forbes's resident orderly/serial-killer (no threat to Hannibal Lecter, though he does keep his dead mom in a freezer) who's been ``liberating'' patients, and who decides that Janet is on to him. A madcap chase to Key West and back winds up with Sean taking Mason hostage. Will a SWAT team neutralize Sean before he can prove that the medulloblastoma protocol is key to an evil scheme to fund the money-starved Clinic? All this antic action, and a Message about the financial plight of medical research too: So what if Janet finds her heart ``pounding and knowing her face is flushed''? Chalk up another big one for Cook. (Literary Guild Dual Selection for Winter)