A fine life, warts and all, of a brilliant scientist and his fight against cancer.
A long-overdue biography of German biologist Otto Warburg (1883-1970), who won the Nobel Prize for his work on cell respiration and metabolism, especially as related to cancer.
Self-confident and assertive, Warburg made his first groundbreaking discovery—that fertilized eggs vastly increased their oxygen consumption—even before receiving his medical degree. By the 1920s, his work on cell metabolism and cancer persuaded the Rockefeller Foundation to give him a yearly grant, followed by funds to build his own research facility at the Kaiser Wilhelm institutes in Berlin. Though occasionally harassed by Nazi officials, he was likely protected by Hitler, a hypochondriac terrified of cancer. Of more than 100 Jews at the institutes in 1933, he was the only one remaining in 1945. As health and science writer Apple shows, the postwar years produced little change in Warburg’s routine, and theories about the pathogenesis of cancer dominated research until the 1960s, when scientists turned their attention to DNA and cancer-causing genes. Since cancer remains unconquered, the 21st century has seen a “metabolism revival.” Apple begins and ends with sections on the nature of cancer, the incidence of which increases as technology progresses. This realization two centuries ago began an intense search for the cause, which is still in progress. The fact that “70 percent or more of cancers were caused by environment factors, a category that includes diet,” is less helpful than it sounds, although avoiding smoking, radiation, and toxic chemicals is recommended. Health gurus confidently prescribe “anticancer diets,” but good research turns up few specifics. Diabetes and obesity increase the risk, so there’s clearly a connection to overnutrition, but Apple admits that the “connection” needs serious narrowing. As the search continues, this book is a welcome addition to the library on the disease and one of its most successful enemies.
A fine life, warts and all, of a brilliant scientist and his fight against cancer.Pub Date: May 25, 2021
ISBN: 978-1-63149-315-7
Page Count: 384
Publisher: Liveright/Norton
Review Posted Online: March 16, 2021
Kirkus Reviews Issue: April 1, 2021
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
A horde-pleaser, well-written and full of surprises.
“The Mongols swept across the globe as conquerors,” writes the appreciative pop anthropologist-historian Weatherford (The History of Money, 1997, etc.), “but also as civilization’s unrivaled cultural carriers.”
No business-secrets fluffery here, though Weatherford does credit Genghis Khan and company for seeking “not merely to conquer the world but to impose a global order based on free trade, a single international law, and a universal alphabet with which to write all the languages of the world.” Not that the world was necessarily appreciative: the Mongols were renowned for, well, intemperance in war and peace, even if Weatherford does go rather lightly on the atrocities-and-butchery front. Instead, he accentuates the positive changes the Mongols, led by a visionary Genghis Khan, brought to the vast territories they conquered, if ever so briefly: the use of carpets, noodles, tea, playing cards, lemons, carrots, fabrics, and even a few words, including the cheer hurray. (Oh, yes, and flame throwers, too.) Why, then, has history remembered Genghis and his comrades so ungenerously? Whereas Geoffrey Chaucer considered him “so excellent a lord in all things,” Genghis is a byword for all that is savage and terrible; the word “Mongol” figures, thanks to the pseudoscientific racism of the 19th century, as the root of “mongoloid,” a condition attributed to genetic throwbacks to seed sown by Mongol invaders during their decades of ravaging Europe. (Bad science, that, but Dr. Down’s son himself argued that imbeciles “derived from an earlier form of the Mongol stock and should be considered more ‘pre-human, rather than human.’ ”) Weatherford’s lively analysis restores the Mongols’ reputation, and it takes some wonderful learned detours—into, for instance, the history of the so-called Secret History of the Mongols, which the Nazis raced to translate in the hope that it would help them conquer Russia, as only the Mongols had succeeded in doing.
A horde-pleaser, well-written and full of surprises.Pub Date: March 2, 2004
ISBN: 0-609-61062-7
Page Count: 320
Publisher: Crown
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Dec. 1, 2003
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.
A warts-and-all portrait of the famed techno-entrepreneur—and the warts are nearly beyond counting.
To call Elon Musk (b. 1971) “mercurial” is to undervalue the term; to call him a genius is incorrect. Instead, Musk has a gift for leveraging the genius of others in order to make things work. When they don’t, writes eminent biographer Isaacson, it’s because the notoriously headstrong Musk is so sure of himself that he charges ahead against the advice of others: “He does not like to share power.” In this sharp-edged biography, the author likens Musk to an earlier biographical subject, Steve Jobs. Given Musk’s recent political turn, born of the me-first libertarianism of the very rich, however, Henry Ford also comes to mind. What emerges clearly is that Musk, who may or may not have Asperger’s syndrome (“Empathy did not come naturally”), has nurtured several obsessions for years, apart from a passion for the letter X as both a brand and personal name. He firmly believes that “all requirements should be treated as recommendations”; that it is his destiny to make humankind a multi-planetary civilization through innovations in space travel; that government is generally an impediment and that “the thought police are gaining power”; and that “a maniacal sense of urgency” should guide his businesses. That need for speed has led to undeniable successes in beating schedules and competitors, but it has also wrought disaster: One of the most telling anecdotes in the book concerns Musk’s “demon mode” order to relocate thousands of Twitter servers from Sacramento to Portland at breakneck speed, which trashed big parts of the system for months. To judge by Isaacson’s account, that may have been by design, for Musk’s idea of creative destruction seems to mean mostly chaos.
Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.Pub Date: Sept. 12, 2023
ISBN: 9781982181284
Page Count: 688
Publisher: Simon & Schuster
Review Posted Online: Sept. 12, 2023
Kirkus Reviews Issue: Oct. 15, 2023
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